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Secretion of S1P from pericytes and astrocytes to retinal microvasculature ECs will promote barrier stability through upregulation of various junctional proteins, as well as the expression of N-cadherin which promotes cell-to-cell interaction (Paik et al., 2004

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This isnt a failing of the medicines it reflects the nature of obesity as a chronic, relapsing condition, said study lead author Sam West, a postdoctoral researcher at the Nuffield Department of Primary Care Health Sciences, University of Oxford, in the statement